Acta2<em1(cre/ERT2)Smoc> Endonuclease-mediated Allele Detail MGI Mouse (MGI:6430180)

Acta2^{em1(cre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Acta2^{em1(cre/ERT2)Smoc}
Name:	actin alpha 2, smooth muscle, aorta; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI ID:	MGI:6430180
Synonyms:	Acta2^{em1(CreERT2-Wpre-polyA)Smoc}
Gene:	Acta2 Location: Chr19:34218490-34232990 bp, - strand Genetic Position: Chr19, 29.41 cM, cytoband C3
Alliance:	Acta2^{em1(cre/ERT2)Smoc} page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Acta2^{em1(cre/ERT2)Smoc} expression driven by 1 gene

Mutation details: CRISPR/Cas9 genome editing technology was used to insert a CreERT2-Wpre-polyA expression cassette into the gene start codon. (J:238766)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Acta2 (mouse) Summary of all recombinase alleles driven by Acta2. Alliance mouse Acta2 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Acta2 Mutation:	57 strains or lines available

References

Original:	J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017;
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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