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Cluem2(dre/ERT2)Smoc
Endonuclease-mediated Allele Detail
Summary
Symbol: Cluem2(dre/ERT2)Smoc
Name: clusterin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
MGI ID: MGI:6430708
Synonyms: Clu-2A-DreER, Cluem2(2A-DreERT2)Smoc
Gene: Clu  Location: Chr14:66206093-66218992 bp, + strand  Genetic Position: Chr14, 34.36 cM
Alliance: Cluem2(dre/ERT2)Smoc page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Cluem2(dre/ERT2)Smoc expression driven by 1 gene
 
Mutation details: CRISPR/Cas9 genome editing technology was used to insert a viral 2A oligopeptide that mediates ribosomal skipping and a Dre/ERT2 fusion recombinase gene cassette into the gene stop codon. (J:238766, J:304636)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Clu (mouse)
Summary of all recombinase alleles driven by Clu.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clu Mutation:  32 strains or lines available
References
Original:  J:304636 Han X, et al., A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. Cell Stem Cell. 2021 Feb 2;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory