Clu<em2(dre/ERT2)Smoc> Endonuclease-mediated Allele Detail MGI Mouse (MGI:6430708)

Clu^{em2(dre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Clu^{em2(dre/ERT2)Smoc}
Name:	clusterin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
MGI ID:	MGI:6430708
Synonyms:	Clu-2A-DreER, Clu^{em2(2A-DreERT2)Smoc}
Gene:	Clu Location: Chr14:66205932-66218996 bp, + strand Genetic Position: Chr14, 34.36 cM
Alliance:	Clu^{em2(dre/ERT2)Smoc} page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Clu^{em2(dre/ERT2)Smoc} expression driven by 1 gene

Mutation details: CRISPR/Cas9 genome editing technology was used to insert a viral 2A oligopeptide that mediates ribosomal skipping and a Dre/ERT2 fusion recombinase gene cassette into the gene stop codon. (J:238766, J:304636)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Clu (mouse) Summary of all recombinase alleles driven by Clu. Alliance mouse Clu gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Clu Mutation:	31 strains or lines available

References

Original:	J:304636 Han X, et al., A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. Cell Stem Cell. 2021 Feb 2;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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