About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:287334 Wunnemann F, et al., Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. Nat Genet. 2020 Jan;52(1):40-47
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6437246
Gene symbol: Adamts19
Gene name: ADAM metallopeptidase with thrombospondin type 1 motif 19
Reporter: lacZ
Direct Detection
Results
Specimen 5A: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: left atrium Present 5A
TS23: right atrium Present 5A
TS23: ventricle cardiac muscle Present 5A Expression is seen in trabeculated myocardium.
Specimen 5B: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: left atrium Present 5B
TS27: right atrium Present 5B
TS27: ventricle cardiac muscle Present 5B Expression is seen in trabeculated myocardium.
Specimen 5C: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: left atrium Present 5C
TS28: right atrium Present 5C
TS28: ventricle cardiac muscle Present 5C Expression is seen in trabeculated myocardium.
Specimen 5D: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: tricuspid valve Present 5D Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5E: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: tricuspid valve Present 5E Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5F: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: tricuspid valve Present 5F Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5G: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: mitral valve Present 5G Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5H: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: mitral valve Present 5H Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5I: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: mitral valve Present 5I Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5J: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: pulmonary valve Present 5J Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5K: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: pulmonary valve Present 5K Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5L: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: pulmonary valve Present 5L Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5M: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: aortic valve Present 5M Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5N: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: pulmonary valve Present 5N Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5O: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: aortic valve Present 5O Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen S7A: embryonic day 10.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS17: heart Absent S7A
TS17: cartilage condensation Weak S7A Weak staining is observed at regions of cartilage formation.
Specimen S7B: embryonic day 12.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS20: bone Strong S7B Strong staining is present in the developing bones and joints.
TS20: skeletal system Strong S7B Strong staining is present in the developing bones and joints.
Specimen S7C: embryonic day 12.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS20: endocardial cushion Weak Diffuse S7C
TS20: left atrium Weak Diffuse S7C
TS20: left ventricle cardiac muscle Weak Diffuse S7C Expression is seen in the trabeculated myocardium.
Specimen S8A: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: left atrium Present S8A
TS27: right atrium Present S8A
TS27: heart left ventricle Present S8A
TS27: heart right ventricle Present S8A
Specimen S8B: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: left atrium Present S8B
TS28: right atrium Present S8B
TS28: heart left ventricle Absent S8B
TS28: heart right ventricle Absent S8B
Specimen S8C: postnatal month 5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: left atrium Present S8C
TS28: right atrium Present S8C
Specimen S8D: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: aortic valve Strong S8D Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS27: mitral valve Strong S8D Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS27: pulmonary valve Strong S8D Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS27: tricuspid valve Strong S8D Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen S8E: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: aortic valve Present S8E Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: mitral valve Present S8E Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: pulmonary valve Present S8E Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: tricuspid valve Present S8E Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen S8F: postnatal month 5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: aortic valve Present S8F Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: mitral valve Present S8F Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: pulmonary valve Present S8F Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: tricuspid valve Present S8F Expression is detected in the interstitial cells, not in the endothelial monolayer.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory