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Pnoctm1.1(cre)Jcbr
Targeted Allele Detail
Summary
Symbol: Pnoctm1.1(cre)Jcbr
Name: prepronociceptin; targeted mutation 1.1, Jens C Bruning
MGI ID: MGI:6448945
Synonyms: PNOC-Cre
Gene: Pnoc  Location: Chr14:65638931-65662908 bp, - strand  Genetic Position: Chr14, 34.33 cM, cytoband D1
Alliance: Pnoctm1.1(cre)Jcbr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:291152
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Pnoctm1.1(cre)Jcbr expression driven by 1 gene
 
Mutation details: A targeting vector was designed that replaces exon 2, containing the ATG translation start-site of Pnoc, with Cre. Flp-mediated recombination removed the neo cassette. The allele is a null. (J:291152)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pnoc (mouse)
Summary of all recombinase alleles driven by Pnoc.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pnoc Mutation:  13 strains or lines available
References
Original:  J:291152 Jais A, et al., PNOC(ARC) Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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11/12/2024
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