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Siglec1tm2(icre)Mtka
Targeted Allele Detail
Summary
Symbol: Siglec1tm2(icre)Mtka
Name: sialic acid binding Ig-like lectin 1, sialoadhesin; targeted mutation 2, Masato Tanaka
MGI ID: MGI:6449968
Synonyms: CD169-cre, Siglec1tm1(cre)Mtka
Gene: Siglec1  Location: Chr2:130911140-130928685 bp, - strand  Genetic Position: Chr2, 63.26 cM, cytoband F-H1
Alliance: Siglec1tm2(icre)Mtka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:286200
Parent Cell Line:  B6JN/1 (ES Cell)
Strain of Origin:  (C57BL/6N x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Siglec1tm2(icre)Mtka expression driven by 1 gene
 
Mutation detailsAn improved Cre recombinase gene with a polyA tail and the neomycin resistance gene replaced the first 28-bp fragment including the endogenous ATG start site in exon 1 of the endogenous gene. (J:286200)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Siglec1 (mouse)
Summary of all recombinase alleles driven by Siglec1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Siglec1 Mutation:  84 strains or lines available
References
Original:  J:286200 Karasawa K, et al., Vascular-resident CD169-positive monocytes and macrophages control neutrophil accumulation in the kidney with ischemia-reperfusion injury. J Am Soc Nephrol. 2015 Apr;26(4):896-906
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory