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Tbx3tm3.1(cre/ERT2)Vmc
Targeted Allele Detail
Summary
Symbol: Tbx3tm3.1(cre/ERT2)Vmc
Name: T-box 3; targeted mutation 3.1, Vincent M Christoffels
MGI ID: MGI:6450136
Synonyms: Tbx3CreERT2
Gene: Tbx3  Location: Chr5:119808734-119822789 bp, + strand  Genetic Position: Chr5, 60.34 cM
Alliance: Tbx3tm3.1(cre/ERT2)Vmc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:266576
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tbx3tm3.1(cre/ERT2)Vmc expression driven by 1 gene
 
Mutation details: The first three codons of the coding region in exon 1 were replaced by an frt-flanked CreERT2-polyA PGK-neo cassette. The PGK-neo cassette was removed via Flp-mediated recombination. (J:266576)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tbx3 (mouse)
Summary of all recombinase alleles driven by Tbx3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx3 Mutation:  49 strains or lines available
Notes
E141B10 embryonic stem (ES) cells were used.
References
Original:  J:266576 Mohan RA, et al., Embryonic Tbx3(+) cardiomyocytes form the mature cardiac conduction system by progressive fate restriction. Development. 2018 Sep 3;145(17):dev167361
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory