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Xcr1tm1.1(icre)Kmm
Targeted Allele Detail
Summary
Symbol: Xcr1tm1.1(icre)Kmm
Name: chemokine (C motif) receptor 1; targeted mutation 1.1, Kenneth Murphy
MGI ID: MGI:6450161
Synonyms: Xcr1Cre
Gene: Xcr1  Location: Chr9:123681380-123691094 bp, - strand  Genetic Position: Chr9, 74.71 cM, cytoband F4
Alliance: Xcr1tm1.1(icre)Kmm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:294175
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Xcr1tm1.1(icre)Kmm expression driven by 1 gene
 
Mutation details: The targeting construct is designed to insert an internal ribosome entry site (IRES), followed by an mCherry fluorescent protein and the codon-improved cre recombinase (icre) sequence separated by a viral T2A oligopeptide that mediates ribosomal skipping, into the 3' UTR. An FRT-flanked neomycin resistance (neo) cassette was inserted 3' of the cre sequence. Flp-mediated recombination removed the FRT-flanked neo cassette (J:294175)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Xcr1 (mouse)
Summary of all recombinase alleles driven by Xcr1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xcr1 Mutation:  33 strains or lines available
References
Original:  J:294175 Ferris ST, et al., cDC1 prime and are licensed by CD4(+) T cells to induce anti-tumour immunity. Nature. 2020 Aug;584(7822):624-629
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory