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Slc9a3tm2.1(cre/ERT2)Niba
Targeted Allele Detail
Summary
Symbol: Slc9a3tm2.1(cre/ERT2)Niba
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3; targeted mutation 2.1, Nick Barker
MGI ID: MGI:6450715
Synonyms: Slc9a3-2A-creERT2
Gene: Slc9a3  Location: Chr13:74269576-74317561 bp, + strand  Genetic Position: Chr13, 40.15 cM
Alliance: Slc9a3tm2.1(cre/ERT2)Niba page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292580
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Slc9a3tm2.1(cre/ERT2)Niba expression driven by 1 gene
 
Mutation details: Sequence for the 2A self-cleaving peptide, a cre-ERT2 fusion gene and a loxP site flanked neomycin resistance gene cassette were inserted immediately before the stop codon. The neo cassette was removed through subsequent cre-mediated recombination. This allele expresses the endogenous peptide and the inserted cre-ERT2 fusion peptide. (J:292580)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc9a3 (mouse)
Summary of all recombinase alleles driven by Slc9a3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc9a3 Mutation:  45 strains or lines available
References
Original:  J:292580 Tan SH, et al., AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature. 2020 Feb;578(7795):437-443
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory