Tectaem1(icre)Dbe
Endonuclease-mediated Allele Detail
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| Symbol: |
Tectaem1(icre)Dbe |
| Name: |
tectorin alpha; endonuclease-mediated mutation 1, Dwight E Bergles |
| MGI ID: |
MGI:6451046 |
| Synonyms: |
Tecta-Cre |
| Gene: |
Tecta Location: Chr9:42240915-42311225 bp, - strand Genetic Position: Chr9, 23.63 cM
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| Alliance: |
Tectaem1(icre)Dbe page
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| Strain of Origin: |
(C57BL/6 x SJL/J)F2
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| Allele Type: |
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Endonuclease-mediated (Recombinase) |
| Mutation: |
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Insertion
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Tectaem1(icre)Dbe expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Tecta (MGI:109575) |
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Mutation details: CRISPR/Cas9 genome editing is used to insert a codon improved cre recombinase (iCre), a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability), and a polyadenylation sequence in place of the start codon of the tectorin alpha (Tecta) gene.
(J:286224)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Tecta
(mouse)
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User Notes:
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Additional information submitted by the research community
Additional information submitted by the research community
A mouse line with Cre expression limited primarily to the sensory epithelium. Cross to TdTomato line reveals sparse labeling of cells within the temporal bone and spiral ganglion neurons. J:286224
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| Original: |
J:286224 Babola TA, et al., Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. Elife. 2020 Jan 8;9:e52160 |
| All: |
3 reference(s) |
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Analysis Tools