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Gene Expression Data
Assay Details
Assay
Reference: J:72911 Murdoch JN, et al., Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet. 2001 Oct 15;10(22):2593-601
Assay type: RNA in situ
MGI Accession ID: MGI:6451127
Gene symbol: Vangl2
Gene name: VANGL planar cell polarity 2
Probe: Lpp1 cDNA1
Probe preparation: Antisense RNA
Results
Specimen 3B: embryonic day 8.5; Vangl2Lp/Vangl2+ (more )
Note: 7-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: future hindbrain Present Regionally restricted 3B Expression is as a midline stripe extending from the midbrain to the upper spinal region.
TS13: future midbrain Present Regionally restricted 3B Expression is as a midline stripe extending from the midbrain to the upper spinal region.
TS13: future spinal cord Present Regionally restricted 3B Expression extends to the site of neural tube closure and declines in a rostro-caudal direction.
TS13: future prosencephalon Present Regionally restricted 3B Expression extends to the occipital region.

Specimen 3C: embryonic day 8.5; Vangl2Lp/Vangl2+ (more )
Note: 7-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: future hindbrain Present Regionally restricted 3C Expression is as a midline stripe extending from the midbrain to the upper spinal region.
TS13: future midbrain Present Regionally restricted 3C Expression is as a midline stripe extending from the midbrain to the upper spinal region.
TS13: future spinal cord Present Regionally restricted 3C Expression extends to the site of neural tube closure and declines in a rostro-caudal direction.
TS13: future prosencephalon Present Regionally restricted 3C Expression extends to the occipital region.

Specimen 3D: embryonic day 8.5; Vangl2Lp/Vangl2Lp (more )
Note: 7-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: future hindbrain Present Regionally restricted 3D Expression is as a midline stripe extending from the midbrain to the upper spinal region.
TS13: future midbrain Present Regionally restricted 3D Expression is as a midline stripe extending from the midbrain to the upper spinal region.
TS13: future spinal cord Present Regionally restricted 3D Expression extends to the site of neural tube closure and declines in a rostro-caudal direction.
TS13: future prosencephalon Present Regionally restricted 3D Expression extends to the occipital region.

Specimen 3E: embryonic day 8.5; Vangl2Lp/Vangl2Lp (more )
Note: 7-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: future hindbrain Present Regionally restricted 3E Expression is as a midline stripe extending from the midbrain to the upper spinal region.
TS13: future midbrain Present Regionally restricted 3E Expression is as a midline stripe extending from the midbrain to the upper spinal region.
TS13: future spinal cord Present Regionally restricted 3E Expression extends to the site of neural tube closure and declines in a rostro-caudal direction.
TS13: future prosencephalon Present Regionally restricted 3E Expression extends to the occipital region.

Specimen 3F: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 3F Expression is as a midline stripe extending from the midbrain into most of the spine with the intensity declining in a rostro-caudal direction.
TS15: future midbrain Present Regionally restricted 3F Expression is as a midline stripe extending from the midbrain into most of the spine with the intensity declining in a rostro-caudal direction.
TS15: future spinal cord Present Regionally restricted 3F Expression is as a midline stripe extending from the midbrain into most of the spine with the intensity declining in a rostro-caudal direction.
TS15: future forebrain Present 3F

Specimen 3G: embryonic day 9.5; Vangl2Lp/Vangl2Lp (more )
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 3G Expression is as a midline stripe extending from the midbrain into most of the spine with the intensity declining in a rostro-caudal direction.
TS15: future midbrain Present Regionally restricted 3G Expression is as a midline stripe extending from the midbrain into most of the spine with the intensity declining in a rostro-caudal direction.
TS15: future spinal cord Present Regionally restricted 3G Expression is as a midline stripe extending from the midbrain into most of the spine with the intensity declining in a rostro-caudal direction.
TS15: future forebrain Present 3G

Specimen 3H: embryonic day 8.5; Vangl2Lp/Vangl2+ (more )
Note: 7-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: future spinal cord neural plate Present Regionally restricted 3H At the level of closure initiation expression is in a ventral-dorsal gradient and is absent in the most dorsal neural plate.
TS13: neural tube floor plate Present 3H

Specimen 3I: embryonic day 8.5; Vangl2Lp/Vangl2Lp (more )
Note: 7-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: future spinal cord neural plate Present Regionally restricted 3I At the level of closure initiation expression is in a ventral-dorsal gradient and is absent in the most dorsal neural plate.
TS13: neural tube floor plate Absent 3I

Specimen 3J: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: neural tube floor plate Absent 3J

Specimen 3K: embryonic day 9.5; Vangl2Lp/Vangl2Lp (more )
Structure Level Pattern Image Note
TS15: neural tube floor plate Absent 3K

Specimen 3L: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future spinal cord Present Regionally restricted 3L Expression is as a midline stripe extending into most of the spine with the intensity declining in a rostro-caudal direction.

Specimen 3M: embryonic day 9.5; Vangl2Lp/Vangl2Lp (more )
Structure Level Pattern Image Note
TS15: future spinal cord Present Regionally restricted 3M Expression is as a midline stripe extending into most of the spine with the intensity declining in a rostro-caudal direction.

Specimen 3N: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: epithelium of vagina Present 3N
TS24: urethra of female Present 3N

Specimen 3O: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: eyelid epithelium Present Regionally restricted 3O Expression is in the outer eyelid epithelium and at the site of eyelid fusion.

Specimen 3P: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: outflow tract Strong Regionally restricted 3P Expression is in the right ventricular outflow tract.

Specimen 3Q: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cochlea Present 3Q

Specimen 4A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: neural tube Present 4A
TS15: neural tube floor plate Weak 4A

Specimen 4C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube Present Regionally restricted 4C Expression is ventral.
TS17: neural tube floor plate Absent 4C

Specimen 4E: embryonic day 9.5; Shhtm1Chg/Shhtm1Chg (more )
Structure Level Pattern Image Note
TS15: neural tube Present Regionally restricted 4E There is uniform expression in the dorso-ventral axis of the neural tube.
TS15: neural tube floor plate Present 4E

Specimen 4F: embryonic day 9.5; Shhtm1Chg/Shhtm1Chg (more )
Structure Level Pattern Image Note
TS15: neural tube Present 4F
TS15: neural tube floor plate Present 4F


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory