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Htr2ctm1.1(icre)Jwso
Targeted Allele Detail
Summary
Symbol: Htr2ctm1.1(icre)Jwso
Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1.1, Jong-Woo Sohn
MGI ID: MGI:6451570
Synonyms: Htr2ciCre
Gene: Htr2c  Location: ChrX:145745509-145980273 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband D-F4
Alliance: Htr2ctm1.1(icre)Jwso page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292866
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Htr2ctm1.1(icre)Jwso expression driven by 1 gene
 
Mutation details: A viral peptide bridge 2A sequence and the codon-improved Cre recombinase (iCre) were inserted into before the stop codon of Htr2c gene by homologous recombination in ES cells. (J:292866)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Htr2c (mouse)
Summary of all recombinase alleles driven by Htr2c.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr2c Mutation:  13 strains or lines available
References
Original:  J:292866 Park S, et al., A neural basis for tonic suppression of sodium appetite. Nat Neurosci. 2020 Mar;23(3):423-432
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory