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Ndrg1tm1(cre/ERT2)Myan
Targeted Allele Detail
Summary
Symbol: Ndrg1tm1(cre/ERT2)Myan
Name: N-myc downstream regulated gene 1; targeted mutation 1, Motoko Yanagita
MGI ID: MGI:6451756
Synonyms: Ndrg1CreERT2
Gene: Ndrg1  Location: Chr15:66801167-66841489 bp, - strand  Genetic Position: Chr15, 29.3 cM, cytoband D3
Alliance: Ndrg1tm1(cre/ERT2)Myan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:261876
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ndrg1tm1(cre/ERT2)Myan expression driven by 1 gene
 
Mutation details: The targeting vector was designed to insert Cre/ERT2 cassette, polyA tail, and loxP-flanked PGK-Neo cassette in the opposite transcriptional orientation to the first exon of the Ndrg1 gene at the position of the initiation codon. The knock-in allele disrupted the first exon, thereby deleting the expression of Ndrg1. (J:261876)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ndrg1 (mouse)
Summary of all recombinase alleles driven by Ndrg1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndrg1 Mutation:  29 strains or lines available
References
Original:  J:261876 Endo T, et al., Exploring the origin and limitations of kidney regeneration. J Pathol. 2015 Jun;236(2):251-63
All:  11 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory