About   Help   FAQ
Gt(ROSA)26Sortm1.1(HIFA/cre/ERT2)Yunz
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1.1(HIFA/cre/ERT2)Yunz
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Zhong Yun
MGI ID: MGI:6452621
Synonyms: R26-O2CreER
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1.1(HIFA/cre/ERT2)Yunz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292024
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J-Aw-J/J
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gt(ROSA)26Sortm1.1(HIFA/cre/ERT2)Yunz expression driven by 1 gene
 
Mutation details: The targeting vector contains from 5' to 3': an adenovirus splice acceptor (SA), the oxygen-dependent degradation (ODD) domain from human HIF1A fused in-frame to the 5' end of Cre recombinase gene fused to the mutated estrogen receptor (cre/ERT2), a polyA tail, and an FRT-flanked neomycin cassette. The HIF1A ODD includes amino acids 371-653 containing prolines P401 and P564. The targeting vector was inserted into intron 1 of the Gt(ROSA)26Sor locus. (J:292024)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor (mouse)
Summary of all recombinase alleles driven by Gt(ROSA)26Sor.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:292024 Lin Q, et al., Generation of a hypoxia-sensing mouse model. Genesis. 2020 Mar;58(3-4):e23352
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory