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Gene Expression Data
Assay Details
Assay
Reference: J:155058 Zhang H, et al., Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009 Dec;126(11-12):958-73
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6458837
Gene symbol: Gcg
Gene name: glucagon
Antibody: anti-glucagon
Results
Specimen 1Bc: embryonic day 13.5; Onecut1tm1.1Mga/Onecut1tm1.1Mga (more )
Note: Double labeled: green - Gcg; red - HNF6 (Onecut1; assay MGI:6458834).
Structure Level Pattern Image Note
TS21: pancreas Present Scattered 1Bc Expressing cells scattered throughout pancreas adjacent to epithelium.
Specimen 1Bd: embryonic day 13.5; Onecut1tm1.1Mga/Onecut1tm1.1Mga, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant. Double labeled: green - Gcg; red - HNF6 (Onecut1; assay MGI:6458834).
Structure Level Pattern Image Note
TS21: pancreas Present Clusters 1Bd Expression in clusters of cells. No reduction in glucagon-expressing clusters.
Specimen 2B: embryonic day 15.5; Onecut1tm1.1Mga/Onecut1tm1.1Mga (more )
Note: Double labeled: green - Gcg; red - HNF6 (Onecut1; assay MGI:6458834).
Structure Level Pattern Image Note
TS23: endocrine pancreas Present Regionally restricted 2B
Specimen 2E: postnatal day 1; Onecut1tm1.1Mga/Onecut1tm1.1Mga (more )
Note: Double labeled: green - Gcg; red - HNF6 (Onecut1; assay MGI:6458834).
Structure Level Pattern Image Note
TS27: endocrine pancreas Present Regionally restricted 2E
Specimen 3A: embryonic day 14.5; Onecut1tm1.1Mga/Onecut1tm1.1Mga (more )
Note: Double labeled: green - Gcg; red - Pdx1 (assay MGI:6458836).
Structure Level Pattern Image Note
TS22: pancreas Present Clusters 3A
Specimen 3B: embryonic day 14.5; Onecut1tm1.1Mga/Onecut1tm1.1Mga, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant. Double labeled: green - Gcg; red - Pdx1 (assay MGI:6458836).
Structure Level Pattern Image Note
TS22: pancreas Present Clusters 3B No reduction in glucagon-expressing clusters.
Specimen 3C: embryonic day 13.5; Onecut1tm1.1Mga/Onecut1tm1.1Mga (more )
Note: Double labeled: red - Gcg; green - Ngn3 (Neurog3; assay MGI:6458838).
Structure Level Pattern Image Note
TS21: pancreas Present Clusters 3C
Specimen 3D: embryonic day 13.5; Onecut1tm1.1Mga/Onecut1tm1.1Mga, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant. Double labeled: red - Gcg; green - Ngn3 (Neurog3; assay MGI:6458838).
Structure Level Pattern Image Note
TS21: pancreas Present Clusters 3D No reduction in glucagon-expressing clusters.
Specimen S2A**: postnatal day 2; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Neurog3-cre)C1Able/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: endocrine pancreas Present S2A**
Specimen S2B**: postnatal day 2; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Onecut1tm1.1Mga/Onecut1tm1.1Mga, Tg(Neurog3-cre)C1Able/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: endocrine pancreas Present S2B**
Specimen E18.5 not shown: embryonic day 18.5; Onecut1tm1.1Mga/Onecut1tm1.1Mga, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: endocrine pancreas Weak Regionally restricted Number of alpha cells was reduced at E18.5.
Specimen Adult not shown: postnatal adult; Onecut1tm1.1Mga/Onecut1tm1.1Mga, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: pancreas Present Regionally restricted Expressing cells abnormally located within multilayered epithelium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
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