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Jchainem1(icre/ERT2)Deep
Endonuclease-mediated Allele Detail
Summary
Symbol: Jchainem1(icre/ERT2)Deep
Name: immunoglobulin joining chain; endonuclease-mediated mutation 1, Deepta Bhattacharya
MGI ID: MGI:6478203
Synonyms: JchainCreERT2
Gene: Jchain  Location: Chr5:88667663-88675667 bp, - strand  Genetic Position: Chr5, 43.7 cM
Alliance: Jchainem1(icre/ERT2)Deep page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Jchainem1(icre/ERT2)Deep expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 technology, the allele was generated to insert an IRES sequence and a CreER(T2) fusion gene into the 3' UTR of the immunoglobulin joining chain locus (Jchain) on chromosome 5. (J:297378)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Jchain (mouse)
Summary of all recombinase alleles driven by Jchain.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jchain Mutation:  24 strains or lines available
References
Original:  J:297378 Wong R, et al., Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. Immunity. 2020 Nov 17;53(5):1078-1094.e7
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory