Adtrpem1Sagh
Endonuclease-mediated Allele Detail
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| Symbol: |
Adtrpem1Sagh |
| Name: |
androgen dependent TFPI regulating protein; endonuclease-mediated mutation 1, Alan Saghatelian |
| MGI ID: |
MGI:6488487 |
| Gene: |
Adtrp Location: Chr13:41916621-42001092 bp, - strand Genetic Position: Chr13, 20.61 cM
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| Alliance: |
Adtrpem1Sagh page
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| Allele Type: |
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Endonuclease-mediated (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: CRISPR/cas9-mediated recombination created a 13 bp deletion in exon 2 upstream of the catalytic threonine (T47) resulting in a frameshift mutation and premature stop codon upstream of the catalytic threonine. Western blot analysis confirmed the absence of expression in brown adipose tissue from homozygous mice.
(J:289837)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Adtrp Mutation: |
22 strains or lines available
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| Original: |
J:289837 Erikci Ertunc M, et al., AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. J Biol Chem. 2020 May 1;295(18):5891-5905 |
| All: |
1 reference(s) |
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Analysis Tools
