Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:94923
Schurov IL, et al., Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Mol Psychiatry. 2004 Dec;9(12):1100-10
|
|
Assay type:
|
Immunohistochemistry
|
|
MGI Accession ID:
|
MGI:6504894
|
|
Gene symbol:
|
Disc1
|
|
Gene name:
|
disrupted in schizophrenia 1
|
|
|
Results
|
Specimen
3a:
postnatal adult
(more  )
Note: Double labeled: red - Disc1; green - Map2 (assay MGI:6504896).
Specimen
3a:
(close  )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Double labeled: red - Disc1; green - Map2 (assay MGI:6504896).
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cortical layer II |
Strong |
Regionally restricted |
3a
|
Expression particularly high in layers II/III and V/VI. Expression colocalized with Map2 indicating expression in neurons,.
|
| TS28: cortical layer III |
Strong |
Regionally restricted |
3a
|
Expression particularly high in layers II/III and V/VI. Expression colocalized with Map2 indicating expression in neurons,.
|
| TS28: cortical layer V |
Strong |
Regionally restricted |
3a
|
Expression particularly high in layers II/III and V/VI. Expression colocalized with Map2 indicating expression in neurons,.
|
| TS28: cortical layer VI |
Strong |
Regionally restricted |
3a
|
Expression particularly high in layers II/III and V/VI. Expression colocalized with Map2 indicating expression in neurons,.
|
Specimen
3b:
postnatal adult
(more )
Note: Double labeled: red - Disc1; green - Map2 (assay MGI:6504896).
Specimen
3b:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Double labeled: red - Disc1; green - Map2 (assay MGI:6504896).
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: hippocampus CA3 |
Strong |
Regionally restricted |
3b
,
3b inset
|
Highest density of expression in pyramidal cells of CA3 region. Expression colocalized with Map2 indicating expression in neurons,.
|
Specimen
3c:
postnatal adult
(more )
Note: Double labeled: red - Disc1; green - Map2 (assay MGI:6504896).
Specimen
3c:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Double labeled: red - Disc1; green - Map2 (assay MGI:6504896).
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: hypothalamus |
Present |
Regionally restricted |
3c inset
,
3c
|
Expression colocalized with Map2 indicating expression in neurons,.
|
Specimen
not shown:
postnatal adult
(more )
Specimen
not shown:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: brainstem |
Present |
Regionally restricted |
|
Expression colocalized with Map2 indicating expression in neurons,.
|
| TS28: cerebellum |
Present |
Regionally restricted |
|
Expression colocalized with Map2 indicating expression in neurons,.
|
| TS28: main olfactory bulb |
Present |
Regionally restricted |
|
Expression colocalized with Map2 indicating expression in neurons,.
|
Specimen
3d:
postnatal adult
(more )
Note: Double labeled: red - Disc1; green - Gfap (assay MGI:6504897).
Specimen
3d:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Double labeled: red - Disc1; green - Gfap (assay MGI:6504897).
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: CA3 pyramidal cell layer |
Strong |
|
3d
,
3d inset
|
Highest density of expression in pyramidal cells of CA3 region. No colocalizeation of expression with Gfap suggesting expression is not in glia.
|
|
Analysis Tools