About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:213694 Cantu C, et al., Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development. Genes Dev. 2014 Sep 1;28(17):1879-84
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6506825
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6
Detection system: Secondary antibody
Results
Specimen 4F WT: embryonic day 10.5 (more )
Note: Double labeled: magenta - Pax6; blue - DAPI.
Structure Level Pattern Image Note
TS17: head surface ectoderm Strong Regionally restricted 4F WT Head ectoderm forming lens pit expresses high levels of Pax6.
TS17: lens pit Present 4F WT Expression higher than in presumptive retina.
TS17: optic cup Weak 4F WT
Specimen 4F Pygo2-KO: embryonic day 10.5; Pygo2tm2Kba/Pygo2tm2Kba (more )
Note: Double labeled: magenta - Pax6; blue - DAPI.
Structure Level Pattern Image Note
TS17: head surface ectoderm Weak Regionally restricted 4F Pygo2-KO Reduced expression in surface head ectoderm.
TS17: optic cup Present 4F Pygo2-KO Stronger expression in presumptive retina.
Specimen 4F Bcl9/9l delta HD1: embryonic day 10.5; Bcl9tm1.1Kba/Bcl9tm1.1Kba, Bcl9ltm1.1Kba/Bcl9ltm1.1Kba (more )
Note: Double labeled: magenta - Pax6; blue - DAPI.
Structure Level Pattern Image Note
TS17: head surface ectoderm Weak Regionally restricted 4F Bcl9/9l-deltaHD1 Reduced expression in surface head ectoderm.
TS17: optic cup Present 4F Bcl9/9l-deltaHD1 Stronger expression in presumptive retina.
Specimen 4F Bcl9/9l delta HD1: embryonic day 10.5; Bcl9tm2.1Kba/Bcl9tm2.1Kba, Bcl9ltm2.1Kba/Bcl9ltm2.1Kba (more )
Note: Double labeled: magenta - Pax6; blue - DAPI.
Structure Level Pattern Image Note
TS17: lens pit Present 4F Bcl9/9l-deltaHD2 Expression comparable to wild-type.
TS17: optic cup Present 4F Bcl9/9l-deltaHD2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory