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Lgr5tm3.1(cre/ERT2)Niba
Targeted Allele Detail
Summary
Symbol: Lgr5tm3.1(cre/ERT2)Niba
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 3.1, Nick Barker
MGI ID: MGI:6507189
Synonyms: Lgr5-2A-creERT2
Gene: Lgr5  Location: Chr10:115286219-115423685 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance: Lgr5tm3.1(cre/ERT2)Niba page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292580
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Lgr5tm3.1(cre/ERT2)Niba expression driven by 1 gene
 
Mutation details: Sequence for the 2A self-cleaving peptide, a cre-ERT2 fusion gene and a loxP site flanked neomycin resistance gene cassette were inserted immediately before the stop codon. The neo cassette was removed through subsequent cre-mediated recombination. This allele expresses the endogenous peptide and the inserted cre-ERT2 fusion peptide. (J:247209, J:292580)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lgr5 (mouse)
Summary of all recombinase alleles driven by Lgr5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr5 Mutation:  58 strains or lines available
References
Original:  J:247209 Leushacke M, et al., Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach. Nat Cell Biol. 2017 Jul;19(7):774-786
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory