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Six3tm4.1(cre/ERT2)Gco
Targeted Allele Detail
Summary
Symbol: Six3tm4.1(cre/ERT2)Gco
Name: sine oculis-related homeobox 3; targeted mutation 4.1, Guillermo Oliver
MGI ID: MGI:6507739
Synonyms: Six3-CreERT2
Gene: Six3  Location: Chr17:85921036-85933619 bp, + strand  Genetic Position: Chr17, 55.42 cM
Alliance: Six3tm4.1(cre/ERT2)Gco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140315
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Six3tm4.1(cre/ERT2)Gco expression driven by 1 gene
 
Mutation details: A cre/ERT2 fusion gene is used to replace part of exon 1, in frame 22 nucleotides downstream from the start codon. A floxed selection cassette is inserted in exon 1 downstream of cre/ERT2. Cre-mediated recombination removed the floxed neo cassette. (J:140315)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Six3 (mouse)
Summary of all recombinase alleles driven by Six3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Six3 Mutation:  13 strains or lines available
Notes
The version of this allele that contains the neomycin selection cassette, Six3tm4(cre/ERT1)Gco, has been analyzed.
References
Original:  J:140315 Geng X, et al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
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