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Lbhd2em1(cre/ERT2)Fuki
Endonuclease-mediated Allele Detail
Summary
Symbol: Lbhd2em1(cre/ERT2)Fuki
Name: LBH domain containing 2; endonuclease-mediated mutation 1, Izumi Fukunaga
MGI ID: MGI:6508398
Synonyms: Lbhd2-IRES-CreERT2
Gene: Lbhd2  Location: Chr12:111373243-111378524 bp, + strand  Genetic Position: Chr12, 60.98 cM
Alliance: Lbhd2em1(cre/ERT2)Fuki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:315131
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6JJcl
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Lbhd2em1(cre/ERT2)Fuki expression driven by 1 gene
 
Mutation details: Using CRISPR/cas9 technology an IRES enhancer sequence, a CreER(T2) fusion gene, and a rabbit globin polyadenylation (rGpA) termination sequence were inserted immediately downstream of the LBH domain containing 2 locus of the Lbhd2 gene on chromosome 12. The construct was electroporated into C57BL/6JJcl-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts, and chimeric mice were bred with C57BL/6JJcl for germline transmission. (J:315131)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lbhd2 (mouse)
Summary of all recombinase alleles driven by Lbhd2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lbhd2 Mutation:  10 strains or lines available
References
Original:  J:315131 Koldaeva A, et al., Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing. J Neurosci. 2021 Jul 28;41(30):6449-6467
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory