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Lyve1em1(Ncre)Jung
Endonuclease-mediated Allele Detail
Summary
Symbol: Lyve1em1(Ncre)Jung
Name: lymphatic vessel endothelial hyaluronan receptor 1; endonuclease-mediated mutation 1, Steffen Jung
MGI ID: MGI:6508985
Synonyms: Lyve1ncre
Gene: Lyve1  Location: Chr7:110449814-110462160 bp, - strand  Genetic Position: Chr7, 57.89 cM, cytoband F2
Alliance: Lyve1em1(Ncre)Jung page
Mutation
origin
Strain of Origin:  C57BL/6JOlaHsd
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Lyve1em1(Ncre)Jung expression driven by 1 gene
 
Mutation details: CRISPR/Cas9 system inserted a cassette encoding a viral 2A oligopeptide (T2A) self-cleaving peptide, that mediates ribosomal skipping, fused to an N-terminal Cre recombinase fragment (NCre), directly downstream of the lymphatic vessel endothelial hyaluronan receptor 1 (Lyve1) gene. (J:302588)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lyve1 (mouse)
Summary of all recombinase alleles driven by Lyve1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lyve1 Mutation:  15 strains or lines available
References
Original:  J:302588 Kim JS, et al., A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages. Immunity. 2021 Jan 12;54(1):176-190.e7
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory