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Adora1em1(cre)Rei
Endonuclease-mediated Allele Detail
Summary
Symbol: Adora1em1(cre)Rei
Name: adenosine A1 receptor; endonuclease-mediated mutation 1, Marc L Reitman
MGI ID: MGI:6509134
Synonyms: Adora1-Cre
Gene: Adora1  Location: Chr1:134126963-134163169 bp, - strand  Genetic Position: Chr1, 58.15 cM, cytoband E4
Alliance: Adora1em1(cre)Rei page
Mutation
origin
Strain of Origin:  (C57BL/6 x DBA)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Adora1em1(cre)Rei expression driven by 1 gene
 
Mutation details: CRISPR/cas9 genome editing is used to insert a T2A peptide sequence and Cre recombinase at the stop codon. T2A sequence adds EGRGSLLTCGDVEENPG to the C terminus of Adora1 and a proline to the N terminus of cre. (J:300669)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Adora1 (mouse)
Summary of all recombinase alleles driven by Adora1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora1 Mutation:  23 strains or lines available
References
Original:  J:300669 Province HS, et al., Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms. PLoS One. 2020;15(12):e0243986
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory