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Batf3tm1(flpo)Tasic
Targeted Allele Detail
Summary
Symbol: Batf3tm1(flpo)Tasic
Name: basic leucine zipper transcription factor, ATF-like 3; targeted mutation 1, Bosiljka Tasic
MGI ID: MGI:6514359
Synonyms: Batf3tm1(flpo)Hze
Gene: Batf3  Location: Chr1:190830611-190841140 bp, + strand  Genetic Position: Chr1, 96.28 cM, cytoband H6
Alliance: Batf3tm1(flpo)Tasic page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Batf3tm1(flpo)Tasic expression driven by 1 gene
 
Mutation details: The targeting vector contained, from 5' to 3', a partial Batf3 sequence within exon 3 up to and including the endogenous stop codon, an internal ribosome entry site 2 sequence (IRES2; allows translation initiation in the middle of an mRNA sequence), a FlpO recombinase gene (a codon-optimized FLPe gene-modified for translation in mammalian cells and higher recombination efficiency in cells and in mice), a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability), a bovine growth hormone polyA sequence, an AttB site, a PGK /gb2 promoter-Neomycin resistance gene-PGK polyA cassette and an AttP site. Chimeric mice were bred with C57BL/6J mice. (J:101977)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Batf3 (mouse)
Summary of all recombinase alleles driven by Batf3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Batf3 Mutation:  18 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory