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Aplnrem3(cre/ERT2)Smoc
Endonuclease-mediated Allele Detail
Summary
Symbol: Aplnrem3(cre/ERT2)Smoc
Name: apelin receptor; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
MGI ID: MGI:6690419
Synonyms: Apj-CreER
Gene: Aplnr  Location: Chr2:84966704-84970267 bp, + strand  Genetic Position: Chr2, 49.45 cM, cytoband E1
Alliance: Aplnrem3(cre/ERT2)Smoc page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Aplnrem3(cre/ERT2)Smoc expression driven by 1 gene
 
Mutation details: Using the CRISPR/Cas9 technology cre/ERT2 cassette was targeted to the translational start codon ATG of the mouse Aplnr gene via homologous recombination. (J:270635)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Aplnr (mouse)
Summary of all recombinase alleles driven by Aplnr.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aplnr Mutation:  30 strains or lines available
References
Original:  J:270635 Zhao H, et al., Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target. Cell Rep. 2018 Oct 30;25(5):1241-1254.e5
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory