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Apoc4em1(cre/ERT2)Hzhu
Endonuclease-mediated Allele Detail
Summary
Symbol: Apoc4em1(cre/ERT2)Hzhu
Name: apolipoprotein C-IV; endonuclease-mediated mutation 1, Hao Zhu
MGI ID: MGI:6704909
Synonyms: Apoc4-CreER
Gene: Apoc4  Location: Chr7:19412009-19415385 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance: Apoc4em1(cre/ERT2)Hzhu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Apoc4em1(cre/ERT2)Hzhu expression driven by 1 gene
 
Mutation details: The allele was generated using CRISPR/Cas9 endonuclease-mediated genome editing to have an IRES enhancer sequence and a CreER(T2) fusion gene inserted immediately downstream of the pyruvate kinase liver and red blood cell locus (Apoc4) on chromosome 7. These sequences and Cas9 nuclease were introduced into single-cell C57BL/6J zygotes and transferred to pseudopregnant females. Progeny were screened by DNA sequencing to identify correctly targeted pups, which were then bred to C57BL/6J mice for germline transmission. (J:304477)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Apoc4 (mouse)
Summary of all recombinase alleles driven by Apoc4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoc4 Mutation:  11 strains or lines available
References
Original:  J:304477 Wei Y, et al., Liver homeostasis is maintained by midlobular zone 2 hepatocytes. Science. 2021 Feb 26;371(6532)
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory