Terttm4(cre/ERT2)Sear
Targeted Allele Detail
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| Symbol: |
Terttm4(cre/ERT2)Sear |
| Name: |
telomerase reverse transcriptase; targeted mutation 4, Steven E Artandi |
| MGI ID: |
MGI:6704920 |
| Synonyms: |
TertCreERT2 |
| Gene: |
Tert Location: Chr13:73775030-73797962 bp, + strand Genetic Position: Chr13, 40.12 cM
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| Alliance: |
Terttm4(cre/ERT2)Sear page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:261807
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| Parent Cell Line: |
JM8.F6 (ES Cell)
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| Strain of Origin: |
C57BL/6N
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Terttm4(cre/ERT2)Sear expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The targeting vector was generated by inserting a codon-optimized intron-CreERT2-NeoR cassette into the endogenous translational start site of Tert in the BAC (RP24-342O18) via recombineering. The targeting vector was linearized and electroporated into JM8/F6 mouse ES cells. Correctly targeted ES clones were selected by Southern blotting and karyotypes, and then injected into ICR/CD-1 blastocysts to generate the knock-in line.
(J:261807)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Tert
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tert Mutation: |
55 strains or lines available
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| Original: |
J:261807 Lin S, et al., Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature. 2018 Apr;556(7700):244-248 |
| All: |
2 reference(s) |
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Analysis Tools
