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Foxl1tm2(cre/ERT2)Khk
Targeted Allele Detail
Summary
Symbol: Foxl1tm2(cre/ERT2)Khk
Name: forkhead box L1; targeted mutation 2, Klaus H Kaestner
MGI ID: MGI:6711487
Synonyms: Foxl1CreERT2-2A-tdTomato, FoxL1CreER-tdTom
Gene: Foxl1  Location: Chr8:121854679-121857383 bp, + strand  Genetic Position: Chr8, 70.34 cM
Alliance: Foxl1tm2(cre/ERT2)Khk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:313017
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Foxl1tm2(cre/ERT2)Khk expression driven by 1 gene
 
Mutation details: The targeting vector contains a Cre recombinase/ERT2 fusion, a viral 2A oligopeptide that mediates ribosomal skipping, and a tdTomato reporter followed by neomycin resistance cassette inserted after the ATG site in exon 1. The insertion deletes 200 bp of the coding sequence rendering the allele null. (J:94077, J:313017)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxl1 (mouse)
Summary of all recombinase alleles driven by Foxl1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxl1 Mutation:  12 strains or lines available
References
Original:  J:313017 Kolev HM, et al., A FoxL1-CreERT-2A-tdTomato Mouse Labels Subepithelial Telocytes. Cell Mol Gastroenterol Hepatol. 2021;12(3):1155-1158.e4
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory