Tg(Prop1-icre)432Sac
Transgene Detail
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| Symbol: |
Tg(Prop1-icre)432Sac |
| Name: |
transgene insertion 432, Sally A Camper |
| MGI ID: |
MGI:6711976 |
| Synonyms: |
Prop1-cre |
| Transgene: |
Tg(Prop1-icre)432Sac Location: unknown
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| Alliance: |
Tg(Prop1-icre)432Sac page
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| Strain of Origin: |
C57BL/6J x (C57BL/6 x DBA/2)F1
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Prop1-icre)432Sac expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Prop1 (MGI:109330) |
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Mutation details: A BAC (RP23-479M11) containing the Prop1 gene was modified by inserting a cassette composed of the sequence encoding a mammalian codon usage optimized cre recombinase (icre), the bovine GH polyadenylation signal and an FRT-flanked kanamycin selection marker, into the exon 2 in frame. Flpe excision removed the kanamycin selection marker. The modified BAC was injected into pronuclei of fertilized oocytes to generate transgenic mice. Three lines, 432, 506, and 517 were genereted, and all 3 lines exhibit cre activity throughout the pituitary anterior lobe at 3 weeks of age.
(J:233898)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Prop1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:233898 Davis SW, et al., All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors. Endocrinology. 2016 Apr;157(4):1385-96 |
| All: |
5 reference(s) |
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Analysis Tools
