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Tg(Nanog-cre/Esr1*)4470Mms
Transgene Detail
Summary
Symbol: Tg(Nanog-cre/Esr1*)4470Mms
Name: transgene insertion 4470, Michael Shen
MGI ID: MGI:6714092
Synonyms: Tg(Nanog-cre/ERT2)4470Mms
Transgene: Tg(Nanog-cre/Esr1*)4470Mms  Location: unknown  
Alliance: Tg(Nanog-cre/Esr1*)4470Mms page
Transgene
origin
Strain of Origin:  C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Nanog-cre/Esr1*)4470Mms expression driven by 1 gene
 
Mutation details: The bacterial artificial chromosome, RP23-406B15, containing Nanog and its regulatory sequences was modified to insert a cDNA encoding Cre/Esr1* fusion protein into the translation initiation start site. Additional sequencing indicates that the fusion is not ERT2, but appears to be a mutant derivative of the mouse estrogen receptor. (J:248397)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nanog (mouse)
Summary of all recombinase alleles driven by Nanog.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:248397 Talos F, et al., A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue. Nat Commun. 2017 Apr 21;8:14662
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory