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Tg(Gata1-cre/ERT2)L259Jeng
Transgene Detail
Summary
Symbol: Tg(Gata1-cre/ERT2)L259Jeng
Name: transgene insertion L259, James Douglas Engel
MGI ID: MGI:6717192
Synonyms: G1BCreERT2
Transgene: Tg(Gata1-cre/ERT2)L259Jeng  Location: unknown  
Alliance: Tg(Gata1-cre/ERT2)L259Jeng page
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Gata1-cre/ERT2)L259Jeng expression driven by 1 gene
 
Mutation details: A tamoxifen-inducible CreER(T2) fusion gene was introduced to the start codon of the mouse Gata1 gene contained within BAC RP23-443E19. The modified BAC was introduced to C57BL/6J zygotes. Lines L245 and L259 were generated and shared similar profiles of the erythroid lineage-specific cre activities. The line L259 was used for the studies. The insertion site and copy number of the transgene are unknown. (J:315683)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gata1 (mouse)
Summary of all recombinase alleles driven by Gata1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:315683 Yu L, et al., An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation. Blood. 2021 Nov 4;138(18):1691-1704
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory