Hexb<em2(cre/ERT2)Mp> Endonuclease-mediated Allele Detail MGI Mouse (MGI:6717342)

Hexb^{em2(cre/ERT2)Mp}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Hexb^{em2(cre/ERT2)Mp}
Name:	hexosaminidase B; endonuclease-mediated mutation 2, Marco Prinz
MGI ID:	MGI:6717342
Synonyms:	Hexb^CreERT2
Gene:	Hexb Location: Chr13:97312839-97334865 bp, - strand Genetic Position: Chr13, 50.66 cM
Alliance:	Hexb^{em2(cre/ERT2)Mp} page

Mutation
origin

Strain of Origin:

C57BL/6N

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Hexb^{em2(cre/ERT2)Mp} expression driven by 1 gene

Mutation details: CRISPR/Cas9 system was used to knockin the T2A-cre/ERT2 cassette into the Hexb locus by injecting mouse embryos on a C57Bl/6N background. (J:306642)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hexb (mouse) Summary of all recombinase alleles driven by Hexb. Comparative matrix view of recombinase activities Alliance mouse Hexb gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hexb Mutation:	91 strains or lines available

References

Original:	J:306642 Masuda T, et al., Novel Hexb-based tools for studying microglia in the CNS. Nat Immunol. 2020 Jul;21(7):802-815
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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