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Doc2bem1(folA/cre)Guru
Endonuclease-mediated Allele Detail
Summary
Symbol: Doc2bem1(folA/cre)Guru
Name: double C2, beta; endonuclease-mediated mutation 1, Channabasavaiah Gurumurthy
MGI ID: MGI:6718299
Synonyms: Doc2bddCre
Gene: Doc2b  Location: Chr11:75659792-75686875 bp, - strand  Genetic Position: Chr11, 45.92 cM
Alliance: Doc2bem1(folA/cre)Guru page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    trimethoprim
Mutation:    Insertion
 
Doc2bem1(folA/cre)Guru expression driven by 1 gene
 
Mutation details: CRISPR/cas9 endonuclease mediated genome editing is used to introduce P2A-trimethoprim(TMP)-inducible cre (ddCre) cassette immediately before the stop codon of Doc2b gene. Cre recombinase is fused to the destabilizing DHFR (or folA) domain, which can be transiently stabilized by the administration of TMP. (J:304624)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Doc2b (mouse)
Summary of all recombinase alleles driven by Doc2b.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Doc2b Mutation:  20 strains or lines available
References
Original:  J:304624 Wu H, et al., Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice. Nat Commun. 2021 Feb 15;12(1):1026
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory