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Tbx1tm1.1(cre/ERT2)Zzhg
Targeted Allele Detail
Summary
Symbol: Tbx1tm1.1(cre/ERT2)Zzhg
Name: T-box 1; targeted mutation 1.1, Zhen Zhang
MGI ID: MGI:6718614
Synonyms: Tbx1E5C
Gene: Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance: Tbx1tm1.1(cre/ERT2)Zzhg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:303592
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tbx1tm1.1(cre/ERT2)Zzhg expression driven by 1 gene
 
Mutation details: An IRES-CreERT2-polyA-SDA-Neo-SDA cassette was inserted into Xcm1 site within the exon 5, which encodes part of the T box domain resulting in a functionally null allele. The neo cassette was self-excised in the ES cells. (J:303592)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tbx1 (mouse)
Summary of all recombinase alleles driven by Tbx1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  36 strains or lines available
References
Original:  J:303592 Wei L, et al., Pharyngeal epithelial deletion of Tbx1 causes caudal pharyngeal arch defect but not cardiac conotruncal anomaly. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1315-1322
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory