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Oprm1tm1.1(cre/ERT2)Dwata
Targeted Allele Detail
Summary
Symbol: Oprm1tm1.1(cre/ERT2)Dwata
Name: opioid receptor, mu 1; targeted mutation 1.1, Dai Watanabe
MGI ID: MGI:6718628
Synonyms: MOR-CreER
Gene: Oprm1  Location: Chr10:6708593-6988209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Alliance: Oprm1tm1.1(cre/ERT2)Dwata page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:302775
Parent Cell Line:  EGR-101 (ES Cell)
Strain of Origin:  C57BL/6NSlc
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Oprm1tm1.1(cre/ERT2)Dwata expression driven by 1 gene
 
Mutation details: A bacterial artificial chromosome (BAC) containing the mouse Oprm1 gene (RP24-112H16) was modified so that the translational stop codon in exon 4 of the Oprm1 gene was replaced by a cassette comprising the T2A sequence, icre/ERT2 gene with stop codon and FRT-flanked neomycin-resistant gene (T2A-iCreERT2-FRT-Neo-FRT). The homologous recombination in the mouse ES cells generated a chimeric mouse which was crossed with CAG-FLPe mice to remove the FRT-flanked neomycin resistance cassette in the offspring. (J:302775)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Oprm1 (mouse)
Summary of all recombinase alleles driven by Oprm1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  54 strains or lines available
References
Original:  J:302775 Okunomiya T, et al., Generation of a MOR-CreER knock-in mouse line to study cells and neural circuits involved in mu opioid receptor signaling. Genesis. 2020 Jan;58(1):e23341
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory