About   Help   FAQ
Eomestm4.1(icre)Rob
Targeted Allele Detail
Summary
Symbol: Eomestm4.1(icre)Rob
Name: eomesodermin; targeted mutation 3.1, Elizabeth J Robertson
MGI ID: MGI:6718928
Synonyms: EomesiCre
Gene: Eomes  Location: Chr9:118307259-118315176 bp, + strand  Genetic Position: Chr9, 70.21 cM, cytoband F3
Alliance: Eomestm4.1(icre)Rob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:306370
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Eomestm4.1(icre)Rob expression driven by 1 gene
 
Mutation details: A targeting vector introduced the coding sequence for improved Cre recombinase (iCre) coding sequence followed by a polyA cassette and a loxP-flanked neomycin-resistance cassette was introduced into the exon 1 start site of the Eomes gene, resulting in deletion of about 500 base pairs of the 5' coding region. Correctly targeted ES cells were transiently transfected with a plasmid encoding cre to remove the neomycin cassette. The resulting cells were used to generate germline chimeras. (J:306370)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Eomes (mouse)
Summary of all recombinase alleles driven by Eomes.
 

Expression
In Mice Carrying this Mutation: 9 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eomes Mutation:  44 strains or lines available
References
Original:  J:306370 Harland LTG, et al., The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nat Cell Biol. 2021 Jan;23(1):61-74
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory