About   Help   FAQ
Hoxa13tm1.1(cre/ERT2)Mtor
Targeted Allele Detail
Summary
Symbol: Hoxa13tm1.1(cre/ERT2)Mtor
Name: homeobox A13; targeted mutation 1.1, Miguel Torres
MGI ID: MGI:6718975
Synonyms: Hoxa13CreER
Gene: Hoxa13  Location: Chr6:52235833-52237865 bp, - strand  Genetic Position: Chr6, 25.41 cM
Alliance: Hoxa13tm1.1(cre/ERT2)Mtor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:301894
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Hoxa13tm1.1(cre/ERT2)Mtor expression driven by 1 gene
 
Mutation details: The targeting vector containing Cre-ERT2-FRT-Neo-FRT-LoxP cassette inserted into exon 1 just downstream of the endogenous ATG site of Hoxa13 gene, replacing 1864 base pairs of the coding region spanning exons 1 and 2 was generated from a C57BL/6 BAC (bacterial artificial chromosome) clone (RPCI23:33N14) using homologous recombination. C57BL/6NTac 129S6/SvEvTac embryonic stem (ES) cells (Taconic) were electroporated with the targeting construct to generate chimera. After germline transmission, the Neo resistance cassette was eliminated by breeding with a Flpe deleter line. (J:301894)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hoxa13 (mouse)
Summary of all recombinase alleles driven by Hoxa13.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa13 Mutation:  29 strains or lines available
References
Original:  J:301894 Delgado I, et al., Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb. Sci Adv. 2020 Jun;6(23):eaaz0742
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory