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Gucy1b2tm4(cre)Mom
Targeted Allele Detail
Summary
Symbol: Gucy1b2tm4(cre)Mom
Name: guanylate cyclase 1, soluble, beta 2; targeted mutation 4, Peter Mombaerts
MGI ID: MGI:6719244
Gene: Gucy1b2  Location: Chr14:62630125-62693738 bp, - strand  Genetic Position: Chr14, 33.21 cM
Alliance: Gucy1b2tm4(cre)Mom page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:307157
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Gucy1b2tm4(cre)Mom expression driven by 1 gene
 
Mutation details: Sequence encoding an IRES followed by Cre recombinase with a nuclear localization signal followed by a second IRES and tau-lacZ followed by an FRT-flanked neomycin selection cassette was inserted immediately downstream of the stop codon, leaving the coding sequence intact with tri-cistronic expression resulting in the co-expression of nuclear-localized cre and the tau-lacZ reporter. (J:307157)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gucy1b2 (mouse)
Summary of all recombinase alleles driven by Gucy1b2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gucy1b2 Mutation:  33 strains or lines available
References
Original:  J:307157 Koike K, et al., Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide. Neuron. 2021 Jun;109:1-16
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory