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Ets2em1Aitn
Endonuclease-mediated Allele Detail
Summary
Symbol: Ets2em1Aitn
Name: E26 avian leukemia oncogene 2, 3' domain; endonuclease-mediated mutation 1, Ayako Isotani
MGI ID: MGI:6719263
Gene: Ets2  Location: Chr16:95503274-95522093 bp, + strand  Genetic Position: Chr16, 56.64 cM, cytoband C3-qter
Alliance: Ets2em1Aitn page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Modified isoform(s))
Mutation:    Intragenic deletion
 
Mutation details: CRISPR/Cas9 technology generated a 205 bp deletion in exon 8. Skin and thymus show a mutant mRNA lacking exon 8 and protein lacking exon 8 is detected in the thymus. (J:306220)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ets2 Mutation:  39 strains or lines available
References
Original:  J:306220 Kishimoto Y, et al., A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models. Sci Rep. 2021 Apr 15;11(1):8297
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory