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Gt(ROSA)26Sortm6(dre/PGR*)Dwi
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm6(dre/PGR*)Dwi
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Douglas J Winton
MGI ID: MGI:6719400
Synonyms: RDrePr
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm6(dre/PGR*)Dwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:301641
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    mifepristone
Mutation:    Insertion
 
Gt(ROSA)26Sortm6(dre/PGR*)Dwi expression driven by 1 gene
 
Mutation details: A splice acceptor site was inserted immediately before the Dre and the mutated human progesterone receptor (PGR) consisting of the Ru486 responsive mutant hormone-binding domain hPR891 was fused to the N-terminus of Dre sequence followed by a bovine growth hormone (BGH) polyadenylation signal and PGK-Puro selection cassette. The targeting vector was inserted into a Gt(ROSA)26Sor site by homologous recombination in ES cells. (J:301641)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor (mouse)
Summary of all recombinase alleles driven by Gt(ROSA)26Sor.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:301641 Thorsen AS, et al., Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing. Dis Model Mech. 2020 Oct 22;:dmm046706
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory