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Drd2tm1(icre)Hike
Targeted Allele Detail
Summary
Symbol: Drd2tm1(icre)Hike
Name: dopamine receptor D2; targeted mutation tm1, Hiroko Ikeda
MGI ID: MGI:6720244
Synonyms: Ddr2Cre(neo), Drd2-iCre
Gene: Drd2  Location: Chr9:49251927-49319477 bp, + strand  Genetic Position: Chr9, 26.72 cM
Alliance: Drd2tm1(icre)Hike page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:301337
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Epitope tag, Null/knockout, Recombinase, Reporter)
Mutation:    Insertion
 
Drd2tm1(icre)Hike expression driven by 1 gene
 
Mutation details: By standard homologous recombination in ES cells, the targeting vector inserted the iCre-IRES-Flag-EGFP-pgk-gb2neo-polyA fragment into the translational initiation site of the Drd2 gene in frame. The RT-PCR showed that Drd2 mRNA was negligible in homozygous mice. It is a null allele. (J:301337)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Drd2 (mouse)
Summary of all recombinase alleles driven by Drd2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  70 strains or lines available
References
Original:  J:301337 Ikeda H, et al., Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves. Sci Rep. 2020 Dec 18;10(1):22347
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory