About   Help   FAQ
Tle4tm1.1(cre/ERT2)Zjh
Targeted Allele Detail
Summary
Symbol: Tle4tm1.1(cre/ERT2)Zjh
Name: transducin-like enhancer of split 4; targeted mutation 1.1, Z Josh Huang
MGI ID: MGI:6720838
Synonyms: Tle4-2A-CreER, Tle4-CreER
Gene: Tle4  Location: Chr19:14425514-14575415 bp, - strand  Genetic Position: Chr19, 9.11 cM
Alliance: Tle4tm1.1(cre/ERT2)Zjh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:323692
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tle4tm1.1(cre/ERT2)Zjh expression driven by 1 gene
 
Mutation details: The allele was generated by inserting a 2A-CreER expression cassette in-frame before the STOP codon of the Tle4 gene. The targeting vectors generated using BAC clones from the RPCI-23&24 library were electroporated into a 129SVj/B6 hybrid ES cell line (v6.5). The Resulting ES cell clones were used for tetraploid complementation to obtain male heterozygous mice. The neo selection cassette was excised by crossing to FlpE strain mice. (J:323692)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tle4 (mouse)
Summary of all recombinase alleles driven by Tle4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tle4 Mutation:  57 strains or lines available
References
Original:  J:323692 Matho KS, et al., Genetic dissection of the glutamatergic neuron system in cerebral cortex. Nature. 2021 Oct;598(7879):182-187
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory