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Foxp2tm1(cre)Zjh
Targeted Allele Detail
Summary
Symbol: Foxp2tm1(cre)Zjh
Name: forkhead box P2; targeted mutation 1, Z Josh Huang
MGI ID: MGI:6720891
Synonyms: Foxp2-Cre
Gene: Foxp2  Location: Chr6:14901348-15441976 bp, + strand  Genetic Position: Chr6, 6.49 cM, cytoband A2
Alliance: Foxp2tm1(cre)Zjh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:323692
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Foxp2tm1(cre)Zjh expression driven by 1 gene
 
Mutation details: The allele was generated by inserting a 2A-cre expression cassette in-frame before the STOP codon of the Foxp2 gene. The targeting vectors generated using BAC clones from the RPCI-23&24 library were electroporated into a 129SVj/B6 hybrid ES cell line (v6.5). The Resulting ES cell clones were used for tetraploid complementation to obtain male heterozygous mice. (J:323692)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxp2 (mouse)
Summary of all recombinase alleles driven by Foxp2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp2 Mutation:  52 strains or lines available
References
Original:  J:323692 Matho KS, et al., Genetic dissection of the glutamatergic neuron system in cerebral cortex. Nature. 2021 Oct;598(7879):182-187
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory