Vim<em2(dre)Bzsh> Endonuclease-mediated Allele Detail MGI Mouse (MGI:6720927)

Vim^em2(dre)Bzsh
Endonuclease-mediated Allele Detail

Summary

Symbol:	Vim^em2(dre)Bzsh
Name:	vimentin; endonuclease-mediated mutation 2, Bin Zhou
MGI ID:	MGI:6720927
Synonyms:	Vim-LSL-Dre
Gene:	Vim Location: Chr2:13579122-13587637 bp, + strand Genetic Position: Chr2, 10.04 cM, cytoband A2
Alliance:	Vim^em2(dre)Bzsh page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:

Endonuclease-mediated (Conditional ready, Recombinase)

Mutation:

Insertion

Vim^em2(dre)Bzsh expression driven by 1 gene

Mutation details: By genome editing using CRISPR-Cas9 technology, a cDNA containing loxp-stop-loxp-Dre-polyA (LSL-Dre) cassette was inserted into the translation start codon of the Vim gene. To strengthen the stability of the transcripts, the woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) was also included following the Dre signal sequence. (J:297057)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Vim (mouse) Summary of all recombinase alleles driven by Vim. Alliance mouse Vim gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Vim Mutation:	40 strains or lines available

References

Original:	J:297057 Li Y, et al., Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell. 2020 Sep 14;54(5):593-607.e5
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24