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Col1a2em1(cre/ERT2)Bzsh
Endonuclease-mediated Allele Detail
Summary
Symbol: Col1a2em1(cre/ERT2)Bzsh
Name: collagen, type I, alpha 2; endonuclease-mediated mutation 1, Bin Zhou
MGI ID: MGI:6721050
Synonyms: Col1a2-2A-CreER
Gene: Col1a2  Location: Chr6:4505618-4541543 bp, + strand  Genetic Position: Chr6, 1.81 cM
Alliance: Col1a2em1(cre/ERT2)Bzsh page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Col1a2em1(cre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: Using the CRISPR/Cas9 technology, the line was generated by inserting a cDNA encoding cre/ERT2 recombinase into the translational stop codon of the Col1a2 gene, following endogenous Col1a2 by the self-cleaving peptide 2A sequence. (J:248362)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Col1a2 (mouse)
Summary of all recombinase alleles driven by Col1a2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a2 Mutation:  120 strains or lines available
References
Original:  J:248362 He L, et al., Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest. 2017 Aug 01;127(8):2968-2981
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory