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Gata4tm2(cre/ERT2)Ykaw
Targeted Allele Detail
Summary
Symbol: Gata4tm2(cre/ERT2)Ykaw
Name: GATA binding protein 4; targeted mutation 2, Yoshiya Kawaguchi
MGI ID: MGI:6724013
Synonyms: Gata4CreERT2
Gene: Gata4  Location: Chr14:63436371-63509141 bp, - strand  Genetic Position: Chr14, 33.24 cM
Alliance: Gata4tm2(cre/ERT2)Ykaw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:301269
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Gata4tm2(cre/ERT2)Ykaw expression driven by 1 gene
 
Mutation details: A CreERT2-pA-PGK-Bsd-pA replaced most of exon 1 after the first ATG of the Gata4 gene via homologous recombination in ES cells. (J:301269)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gata4 (mouse)
Summary of all recombinase alleles driven by Gata4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:  36 strains or lines available
References
Original:  J:301269 Sankoda N, et al., Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice. Nat Commun. 2021 Jan 25;12(1):560
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory