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Qrfptm2.1(icre)Stak
Targeted Allele Detail
Summary
Symbol: Qrfptm2.1(icre)Stak
Name: pyroglutamylated RFamide peptide; targeted mutation 2.1, Takeshi Sakurai
MGI ID: MGI:6724026
Synonyms: QrfpiCre
Gene: Qrfp  Location: Chr2:31696180-31700592 bp, - strand  Genetic Position: Chr2, 21.89 cM
Alliance: Qrfptm2.1(icre)Stak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:294111
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Qrfptm2.1(icre)Stak expression driven by 1 gene
 
Mutation details: A targeting vector was designed to replace the entire coding region of the prepro-Qrfp sequence in exon 2 of the Qrfp gene with iCre and a pgk-Neo cassette so that the endogenous Qrfp promoter drives the expression of iCre. The Pgk-Neo cassette was deleted by crossing the mice with FLP66 mice. It is a knock-in, knock-out allele. (J:294111)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Qrfp (mouse)
Summary of all recombinase alleles driven by Qrfp.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Qrfp Mutation:  11 strains or lines available
References
Original:  J:294111 Takahashi TM, et al., A discrete neuronal circuit induces a hibernation-like state in rodents. Nature. 2020 Jul;583(7814):109-114
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory