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Hcn4em1(dre/ERT2)Smoc
Endonuclease-mediated Allele Detail
Summary
Symbol: Hcn4em1(dre/ERT2)Smoc
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI ID: MGI:6724251
Synonyms: Hcn4-DreER, Hcn4em1(kozak-DreER-WPRE-A)Smoc
Gene: Hcn4  Location: Chr9:58730695-58770458 bp, + strand  Genetic Position: Chr9, 31.8 cM, cytoband C
Alliance: Hcn4em1(dre/ERT2)Smoc page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Hcn4em1(dre/ERT2)Smoc expression driven by 1 gene
 
Mutation details: A kozak-DreER-WPRE-pA expression cassette was knocked into the Hcn4 gene start codon site via CRISPR/Cas9 mediated recombination. (J:238766, J:304636)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hcn4 (mouse)
Summary of all recombinase alleles driven by Hcn4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcn4 Mutation:  67 strains or lines available
References
Original:  J:304636 Han X, et al., A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. Cell Stem Cell. 2021 Feb 2;
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory