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Cdkn2atm1(cre/ERT2)Mkt
Targeted Allele Detail
Summary
Symbol: Cdkn2atm1(cre/ERT2)Mkt
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Makoto Nakanishi
MGI ID: MGI:6726124
Synonyms: p16-CreERT2, p16Ink4a-CreERT2neo
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance: Cdkn2atm1(cre/ERT2)Mkt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:300221
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Cdkn2atm1(cre/ERT2)Mkt expression driven by 1 gene
 
Mutation details: The exon 1 alpha of the Cdkn2a gene was replaced with a translation start site, a CreERT2 expression cassette and a neo cassette. The retained neo-resistant gene markedly resulted in higher labeling efficacy at this locus presumably due to the fact that a retained neo-resistant cassette can act as a local enhancer to augment reporter expression without compromising tissue reporter fidelity. (J:300221)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdkn2a (mouse)
Summary of all recombinase alleles driven by Cdkn2a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  67 strains or lines available
References
Original:  J:300221 Omori S, et al., Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16(high) Cells In Vivo. Cell Metab. 2020 Nov 3;32(5):814-828.e6
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory