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Tg(Runx1/Hspa1a-cre/ERT2)3-17Itoy
Transgene Detail
Summary
Symbol: Tg(Runx1/Hspa1a-cre/ERT2)3-17Itoy
Name: transgene insertion 3-17, Yoshiaki Ito
MGI ID: MGI:6726411
Synonyms: eR1-CreERT2(3-17)
Transgene: Tg(Runx1/Hspa1a-cre/ERT2)3-17Itoy  Location: unknown  
Alliance: Tg(Runx1/Hspa1a-cre/ERT2)3-17Itoy page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Runx1/Hspa1a-cre/ERT2)3-17Itoy expression driven by 1 gene
 
Mutation details: The transgenic construct contains mouse Runx1 enhancer element sequence (eR1) and the mouse Hspa1a (heat-shock protein 68) basal promoter sequence driving the expression of cre/ERT2. More than 10 founder lines were generated. The line TG(5-2) with higher copy number and TG(3-7) with lower copy number used for studies. Although the former had higher Cre recombinase activity than the latter, the results obtained using these lines were qualitatively indistinguishable. (J:299420)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Runx1 (mouse)
Summary of all recombinase alleles driven by Runx1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:299420 Matsuo J, et al., Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice. Gastroenterology. 2017 Jan;152(1):218-231.e14
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory